Investigating how specific genetic variations influence Alzheimer's disease risk
Establishing Genotype-to-Phenotype Relationships Between Alzheimer’s Related BIN1 Variants
['FUNDING_R21'] · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · NIH-10525652
This study is looking at how changes in a specific gene called BIN1 might affect the risk of getting Alzheimer's disease, and it's for anyone interested in understanding more about the genetic factors behind this condition.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ARIZONA STATE UNIVERSITY-TEMPE CAMPUS (nih funded) |
| Locations | 1 site (TEMPE, UNITED STATES) |
| Trial ID | NIH-10525652 on ClinicalTrials.gov |
What this research studies
This research explores the relationship between genetic variations in the BIN1 gene and the risk of developing Alzheimer's disease. By utilizing advanced gene editing techniques, researchers will introduce specific BIN1 variants into stem cells derived from both healthy individuals and Alzheimer's patients. The study aims to understand how these genetic changes affect key processes related to Alzheimer's, such as amyloid processing and tau protein behavior, using innovative 3-D cell culture models. Through this approach, the research seeks to uncover the mechanisms by which BIN1 variants may influence the development and progression of Alzheimer's disease.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a family history of Alzheimer's disease or those diagnosed with early-stage Alzheimer's.
Not a fit: Patients with other forms of dementia unrelated to Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into Alzheimer's disease mechanisms and potential therapeutic targets.
How similar studies have performed: Previous research has shown promising results in understanding genetic factors related to Alzheimer's disease, making this approach both relevant and potentially impactful.
Where this research is happening
TEMPE, UNITED STATES
- ARIZONA STATE UNIVERSITY-TEMPE CAMPUS — TEMPE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BRAFMAN, DAVID A — ARIZONA STATE UNIVERSITY-TEMPE CAMPUS
- Study coordinator: BRAFMAN, DAVID A
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer's Disease, Alzheimer disease, Alzheimer syndrome, Alzheimer's disease dementia, Alzheimers disease