Investigating how specific genes influence behavior in fruit fly intestinal stem cells
Official title: Genetic interactions among targets of master regulator genes as drivers of complex behavior in Drosophila intestinal stem cells
Funded at California State University Northridge · NIH-10896922 · Data updated 2026-11-12
This study is looking at how certain genes work together in fruit fly gut cells to help us understand how stem cells grow and change, which could eventually help with healing and regeneration in medicine.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | California State University Northridge NIH-funded |
| Lab location | 1 site (Northridge, United States) |
| Project start | August 1, 2023 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $147,500 |
| NIH project number | 5R16GM149452-02 |
| Project ID | NIH-10896922 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for benefiting from this research would be individuals interested in advancements in stem cell therapies and regenerative medicine.
✕Less likely to help
Patients with conditions unrelated to stem cell therapy or those not interested in genetic research may not receive direct benefits from this research.
What this research studies
This research explores the interactions among master regulator genes and their downstream targets in fruit fly intestinal stem cells. By manipulating specific genes, the study aims to understand how these interactions affect stem cell behavior, including their growth and differentiation. The research utilizes the fruit fly Drosophila melanogaster as a model organism, employing advanced genetic techniques to assess the impact of these manipulations on intestinal health. The findings could provide insights into the fundamental mechanisms of stem cell regulation and their potential applications in regenerative medicine.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in understanding stem cell behavior, which may enhance regenerative medicine strategies for various diseases.
How similar studies have gone: While the specific approach of this research is novel, previous studies have shown success in understanding gene interactions in stem cells, indicating potential for impactful findings.
Where this research is happening
-
California State University Northridge
Northridge, United States Active
Researchers
- Principal investigator: Loza Coll, Mariano a — California State University Northridge
- Study coordinator: Loza Coll, Mariano a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.