Investigating how specific genes affect brain development related to autism.
Foxp-regulated signaling pathways in brain development
This study is looking at how two specific genes, FOXP1 and FOXP2, affect brain development and their link to autism, using rodent models to see how these genes influence brain cells and their functions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-11121794 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of certain genes, specifically FOXP1 and FOXP2, in brain development and their connection to autism spectrum disorders. By using rodent models, the researchers will explore how these genes influence the development of brain cells and their functions. The study employs advanced techniques like single-cell RNA sequencing to analyze gene expression changes in specific cell types. The goal is to uncover the molecular pathways that may be disrupted in individuals with neurodevelopmental disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with autism spectrum disorders or those with a family history of neurodevelopmental disorders.
Not a fit: Patients without autism spectrum disorders or related neurodevelopmental conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the biological mechanisms underlying autism, potentially informing future treatments or interventions.
How similar studies have performed: Previous research has shown promising results in understanding the genetic basis of autism through similar approaches, indicating a potential for success in this study.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Konopka, Genevieve — Ut Southwestern Medical Center
- Study coordinator: Konopka, Genevieve
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.