Investigating how specific genes affect brain development in children
Roles of Gsx factors in basal ganglia development
This study is looking at how certain genes affect the development of a brain area important for movement and behavior, using mice that have similar genetic traits to humans, to help us understand conditions like ADHD in kids.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project ID | NIH-11004956 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of Gsx factors in the development of the basal ganglia, a critical area of the brain involved in movement and behavior. By studying mouse models that mimic human genetic variants, researchers aim to uncover how these genetic factors influence the formation of neural circuits during early brain development. The project involves analyzing gene expression and the resulting effects on neuronal subtype specification, which could provide insights into conditions like ADHD and other neurological disorders in children.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-11 years who exhibit symptoms of ADHD or have been identified with genetic variants related to brain development.
Not a fit: Patients who are older than 11 years or do not have any neurological symptoms or genetic variants related to the study may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and potential treatments for children with ADHD and related neurological conditions.
How similar studies have performed: Previous studies have shown success in understanding the genetic basis of neurological disorders through similar approaches, indicating that this research builds on established findings.
Where this research is happening
Cincinnati, United States
- Cincinnati Childrens Hosp Med Ctr — Cincinnati, United States (Active)
Researchers
- Principal investigator: Campbell, Kenneth J — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Campbell, Kenneth J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.