Investigating how specific gene mutations contribute to lymphoma development
Role of CREBBP missense mutations in lymphomagenesis
This study is looking at how changes in the CREBBP gene might influence the growth of certain types of non-Hodgkin lymphoma, like diffuse large B-cell lymphoma and follicular lymphoma, to find new ways to improve treatment for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11003707 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of CREBBP gene mutations in the development of non-Hodgkin lymphomas, particularly diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL). By examining how these mutations affect tumor biology and progression, the study aims to identify potential therapeutic targets that could improve treatment outcomes. The approach involves analyzing genetic alterations and their impact on tumor behavior, which may lead to more effective strategies for managing these cancers.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with diffuse large B-cell lymphoma or follicular lymphoma, particularly those with advanced stages of the disease.
Not a fit: Patients with lymphomas that do not involve CREBBP mutations or those with other unrelated cancers may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new targeted therapies that improve survival rates for patients with aggressive forms of lymphoma.
How similar studies have performed: Previous research has shown that targeting genetic mutations in cancer can lead to significant advancements in treatment, suggesting that this approach may also yield promising results.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Pasqualucci, Laura — Columbia University Health Sciences
- Study coordinator: Pasqualucci, Laura
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.