Investigating how specific enzymes can transform inert chemical bonds using oxygen
One, Two, and Three Rieske Routes for Catalyzing Site-Specific Oxygenations
['FUNDING_OTHER'] · UNIVERSITY OF MICHIGAN AT ANN ARBOR · NIH-10828316
This study is looking at special enzymes that help make important medicines and clean up pollution, which could lead to better treatments for patients needing things like anesthetics or antibiotics.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MICHIGAN AT ANN ARBOR (nih funded) |
| Locations | 1 site (ANN ARBOR, UNITED STATES) |
| Trial ID | NIH-10828316 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how Rieske oxygenases, a type of enzyme, utilize transition metals and molecular oxygen to catalyze specific chemical transformations. By studying these enzymes, the research aims to uncover their mechanisms and potential applications in producing pharmaceuticals and cleaning up environmental pollutants. Patients may benefit from advancements in drug development and improved treatments for conditions requiring anesthetics or antibiotics. The research employs biochemical techniques to analyze enzyme activity and efficiency.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals requiring new antibiotic or anesthetic treatments.
Not a fit: Patients with conditions unrelated to antibiotic or anesthetic treatments may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and targeted treatments for various medical conditions, including infections and pain management.
How similar studies have performed: Previous research has shown success in utilizing similar enzymatic approaches for drug development and bioremediation, indicating a promising avenue for this study.
Where this research is happening
ANN ARBOR, UNITED STATES
- UNIVERSITY OF MICHIGAN AT ANN ARBOR — ANN ARBOR, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BRIDWELL-RABB, JENNIFER D — UNIVERSITY OF MICHIGAN AT ANN ARBOR
- Study coordinator: BRIDWELL-RABB, JENNIFER D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.