Investigating how specific enzymes affect liver disease caused by alcohol.
Official title: The role of H3K4 demethylases in alcohol-associated liver disease development and resolution
Funded at University of Kansas Medical Center · NIH-11176036 · Data updated 2026-11-12
This study is looking into how alcohol affects liver cells and the role of certain enzymes in liver disease, with the hope of finding new treatments for people struggling with alcohol-related liver problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kansas Medical Center NIH-funded |
| Lab location | 1 site (Kansas City, United States) |
| Project start | September 1, 2024 |
| Project end | May 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $512,960 |
| NIH project number | 5R01AA031270-02 |
| Project ID | NIH-11176036 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with alcohol-associated liver disease or those at risk due to alcohol consumption.
✕Less likely to help
Patients with liver disease not related to alcohol consumption may not benefit from this research.
What this research studies
This research focuses on understanding the mechanisms behind alcohol-associated liver disease (ALD), which is a significant cause of alcohol-related deaths. By utilizing advanced techniques like single cell sequencing, the study examines how alcohol alters communication between liver cells and the role of specific enzymes called KDM5 demethylases in this process. The research aims to uncover how these enzymes contribute to both the development and resolution of liver disease, potentially leading to new therapeutic strategies for patients affected by ALD.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve outcomes for patients suffering from alcohol-associated liver disease.
How similar studies have gone: While the specific focus on KDM5 demethylases in ALD is novel, similar research approaches have shown promise in understanding liver diseases and their treatment.
Where this research is happening
-
University of Kansas Medical Center
Kansas City, United States Active
Researchers
- Principal investigator: Tikhanovich, Irina — University of Kansas Medical Center
- Study coordinator: Tikhanovich, Irina
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.