Investigating how specific enzymes affect hormone and drug metabolism in the body
Official title: Structure-Function Studies of the Human Cytochrome P450 27 Family
Funded at Appalachian State University · NIH-10857247 · Data updated 2026-11-12
This study is looking at special proteins in our body that help break down hormones and medications, and it's trying to find ways to make new treatments that work better and have fewer side effects for people with different health issues.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Appalachian State University NIH-funded |
| Lab location | 1 site (Boone, United States) |
| Project start | September 5, 2022 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $345,000 |
| NIH project number | 5R35GM147276-03 |
| Project ID | NIH-10857247 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions affected by steroid hormone metabolism, such as certain cancers or metabolic disorders.
✕Less likely to help
Patients with conditions unrelated to hormone or drug metabolism may not receive any benefit from this research.
What this research studies
This research focuses on the human cytochrome P450 27 family of enzymes, which play a crucial role in metabolizing steroid hormones, drugs, and carcinogens. By examining the structure and function of these enzymes, the research aims to understand how they interact with a partner protein called adrenodoxin, which can influence their activity. The goal is to develop targeted therapies that can safely modulate enzyme activity, potentially leading to improved treatments for various health conditions. Patients may benefit from new drug therapies that are more effective and have fewer side effects.
Why it matters
Potential benefit: If successful, this research could lead to the development of safer and more effective therapies for conditions related to hormone and drug metabolism.
How similar studies have gone: Previous research on cytochrome P450 enzymes has led to significant advancements in drug therapy, indicating a strong potential for success in this area.
Where this research is happening
-
Appalachian State University
Boone, United States Active
Researchers
- Principal investigator: Reddish, Michael Jerrell — Appalachian State University
- Study coordinator: Reddish, Michael Jerrell
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.