Investigating how specific enzymes affect DNA methylation patterns in the brain related to autism.
The role of H3K36 methyltransferases on non-CpG methylation patterning in the mammalian brain
This study is looking at how certain proteins in the brain affect the way DNA is marked, which might help us understand autism and other brain development issues, with the hope of finding new ways to help those affected.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-10917342 on NIH RePORTER |
What this research studies
This research explores the role of H3K36 methyltransferases in shaping DNA methylation patterns in the mammalian brain, particularly focusing on how these patterns may relate to autism and other neurodevelopmental disorders. By examining the unique methylation that occurs outside of the traditional CpG context, the study aims to uncover the mechanisms that govern neuronal development and function. The research employs genetic and molecular techniques to identify how disruptions in these processes may contribute to autism, potentially leading to new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with autism spectrum disorder (ASD) or related neurodevelopmental disorders, spanning both children and adults.
Not a fit: Patients with neurodevelopmental disorders not related to autism or those without genetic factors influencing DNA methylation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of autism and the development of targeted therapies that address its underlying biological mechanisms.
How similar studies have performed: While the specific focus on H3K36 methyltransferases and non-CpG methylation in the context of autism is relatively novel, previous studies have shown success in linking epigenetic modifications to neurodevelopmental disorders.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Hamagami-Samson, Nicole — Washington University
- Study coordinator: Hamagami-Samson, Nicole
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.