Investigating how specific DNA structures affect gene expression
Gene Expression Modulated by G4, R-loop and DNA Supercoiling
['FUNDING_R01'] · BOSTON CHILDREN'S HOSPITAL · NIH-11049031
This study is looking at special structures in our DNA and RNA that might help control how genes work, especially in cancer, to find new ways to treat the disease.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BOSTON CHILDREN'S HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11049031 on ClinicalTrials.gov |
What this research studies
This research explores the role of G-quadruplexes (G4) and R-loops in regulating gene expression. By examining how these structures form in DNA and RNA, the study aims to understand their impact on transcription and translation processes. The researchers will utilize various biochemical tools to analyze how these structures can enhance or inhibit gene activity, particularly in cancer-related genes. This work could lead to new insights into the mechanisms of gene regulation and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with cancers that may be influenced by the regulation of oncogenes.
Not a fit: Patients with non-cancerous conditions or those whose cancers are not driven by the genes being studied may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for targeting gene expression in cancer treatment.
How similar studies have performed: Previous studies have shown promising results in understanding the role of G4 structures in gene regulation, indicating that this approach has potential for significant breakthroughs.
Where this research is happening
BOSTON, UNITED STATES
- BOSTON CHILDREN'S HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MYONG, SUA — BOSTON CHILDREN'S HOSPITAL
- Study coordinator: MYONG, SUA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Anti-Cancer Agents, anti-cancer drug