Investigating how specific DNA structures affect gene expression
Official title: Gene Expression Modulated by G4, R-loop and DNA Supercoiling
Funded at Boston Children's Hospital · NIH-11049031 · Data updated 2026-11-12
This study is looking at special structures in our DNA and RNA that might help control how genes work, especially in cancer, to find new ways to treat the disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | March 21, 2023 |
| Project end | February 28, 2027 |
| Funding year | 2025 |
| Award (this year) | $318,600 |
| NIH project number | 5R01GM149729-04 |
| Project ID | NIH-11049031 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with cancers that may be influenced by the regulation of oncogenes.
✕Less likely to help
Patients with non-cancerous conditions or those whose cancers are not driven by the genes being studied may not benefit from this research.
What this research studies
This research explores the role of G-quadruplexes (G4) and R-loops in regulating gene expression. By examining how these structures form in DNA and RNA, the study aims to understand their impact on transcription and translation processes. The researchers will utilize various biochemical tools to analyze how these structures can enhance or inhibit gene activity, particularly in cancer-related genes. This work could lead to new insights into the mechanisms of gene regulation and potential therapeutic targets.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for targeting gene expression in cancer treatment.
How similar studies have gone: Previous studies have shown promising results in understanding the role of G4 structures in gene regulation, indicating that this approach has potential for significant breakthroughs.
Where this research is happening
-
Boston Children's Hospital
Boston, United States Active
Researchers
- Principal investigator: Myong, Sua — Boston Children's Hospital
- Study coordinator: Myong, Sua
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.