Investigating how specific DNA modifications affect neural stem cell biology
Official title: Tet-mediated DNA hydroxylation vs formylation and carboxylation in NSC biology
Funded at Albert Einstein College of Medicine · NIH-11098417 · Data updated 2026-11-12
This study is looking at how certain changes in DNA affect the behavior of brain stem cells, which could help us understand how these cells grow and develop, especially for people interested in brain health and diseases.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albert Einstein College of Medicine NIH-funded |
| Lab location | 1 site (Bronx, United States) |
| Project start | April 16, 2024 |
| Project end | April 15, 2027 |
| Funding year | 2025 |
| Award (this year) | $54,538 |
| NIH project number | 5F30HD113183-02 |
| Project ID | NIH-11098417 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research would include individuals with conditions affecting neural stem cells or related neurological disorders.
✕Less likely to help
Patients with conditions unrelated to neural stem cell biology or those not affected by neurological disorders may not benefit from this research.
What this research studies
This research focuses on understanding the roles of different DNA modifications in neural stem cells (NSCs). It examines how enzymes from the Ten-Eleven Translocation (Tet) family influence gene regulation by converting 5-methylcytosine into various forms, including hydroxymethylcytosine, formylcytosine, and carboxylcytosine. By creating specific mutations in these enzymes, researchers aim to differentiate NSCs and observe how these modifications impact their biological functions and gene expression. This could provide insights into the epigenetic mechanisms that govern NSC behavior.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for manipulating neural stem cell behavior, which may have implications for treating neurological disorders and brain injuries.
How similar studies have gone: While the specific approach of uncoupling DNA modifications in NSCs is novel, similar research has shown promise in understanding epigenetic regulation in other cell types.
Where this research is happening
-
Albert Einstein College of Medicine
Bronx, United States Active
Researchers
- Principal investigator: Ebert, Blake C — Albert Einstein College of Medicine
- Study coordinator: Ebert, Blake C
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.