Investigating how specific channels in the brain affect signaling and fluid balance.
Official title: Role of LRRC8 Anion Channels in Brain Taurine Signaling and Body Fluid Homeostasis
Funded at Albany Medical College · NIH-11036466 · Data updated 2026-11-12
This study is looking at special channels in the brain that help control cell size and communication between brain cells, which could help us understand and manage conditions like seizures and fluid balance issues.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albany Medical College NIH-funded |
| Lab location | 1 site (Albany, United States) |
| Project start | December 1, 2024 |
| Project end | November 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $245,938 |
| NIH project number | 1R21NS140782-01 |
| Project ID | NIH-11036466 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research are adolescents aged 12-20 who may have neurological conditions or are at risk for seizures.
✕Less likely to help
Patients outside the age range of 12-20 or those without neurological conditions may not receive direct benefits from this research.
What this research studies
This research focuses on the role of volume-regulated anion channels (VRACs) in the brain, which are crucial for controlling cell volume and signaling. By studying these channels, the research aims to understand how they influence the release of neurotransmitters and their impact on conditions like seizures and fluid balance in the body. The approach involves using genetically modified mice to explore the effects of these channels on brain function and overall health. Patients may benefit from insights gained about managing neurological conditions linked to these channels.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating neurological disorders such as epilepsy and improving fluid balance in the body.
How similar studies have gone: Previous research has shown that targeting similar channels can lead to significant advancements in understanding and treating neurological disorders.
Where this research is happening
-
Albany Medical College
Albany, United States Active
Researchers
- Principal investigator: Mongin, Alexander a — Albany Medical College
- Study coordinator: Mongin, Alexander a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.