Investigating how specific channels in lymphatic cells affect obesity
Lymphatic Endothelial Piezo1-TRPV4 Channel Signaling in Obesity
['FUNDING_CAREER'] · UNIVERSITY OF VIRGINIA · NIH-11035059
This study is looking at how certain cells in our lymphatic system might affect weight gain and health problems related to obesity, focusing on specific channels that help these cells work properly, and it aims to find ways to fix these issues to help people manage their weight better.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF VIRGINIA (nih funded) |
| Locations | 1 site (CHARLOTTESVILLE, UNITED STATES) |
| Trial ID | NIH-11035059 on ClinicalTrials.gov |
What this research studies
This research explores the role of lymphatic endothelial cells (LECs) in obesity, focusing on how their signaling pathways may contribute to weight gain and related health issues. The study examines the function of ion channels, specifically TRPV4 and Piezo1, in regulating lymphatic barrier integrity and how their dysfunction can lead to adipose tissue accumulation. By using mouse models, the research aims to identify the mechanisms behind lymphatic dysfunction in obesity and how these pathways can be targeted for therapeutic interventions.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 years old who are experiencing obesity or related metabolic disorders.
Not a fit: Patients who are not overweight or do not have obesity-related health issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for obesity and its associated health risks, such as cardiovascular disease and stroke.
How similar studies have performed: Other research has shown promising results in understanding lymphatic function and its impact on obesity, suggesting that this approach could yield valuable insights.
Where this research is happening
CHARLOTTESVILLE, UNITED STATES
- UNIVERSITY OF VIRGINIA — CHARLOTTESVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHEN, YEN-LIN — UNIVERSITY OF VIRGINIA
- Study coordinator: CHEN, YEN-LIN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.