Investigating how specific cell types affect treatment outcomes in triple negative breast cancer.
Distinct contributions of mesenchymal cell niches in the therapeutic potential of the hedgehog pathway in triple negative breast cancer
['FUNDING_OTHER'] · UNIVERSITY OF PUERTO RICO MAYAGUEZ · NIH-10724829
This study is looking at how certain cells in the body affect the success of new treatments for triple negative breast cancer, with the hope of finding better ways to help patients feel better and fight their cancer.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PUERTO RICO MAYAGUEZ (nih funded) |
| Locations | 1 site (MAYAGUEZ, UNITED STATES) |
| Trial ID | NIH-10724829 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of mesenchymal cells in the effectiveness of Hedgehog (Hh) inhibitors for treating triple negative breast cancer (TNBC). By developing advanced in vitro models that mimic the tumor environment, the study aims to identify how different types of mesenchymal cells influence tumor growth and response to therapy. The researchers will analyze the interactions between these cells and the Hh signaling pathway to uncover potential new therapeutic targets. This approach could lead to more effective treatment strategies for patients with TNBC.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with triple negative breast cancer who may benefit from targeted therapies.
Not a fit: Patients with non-triple negative breast cancer types are unlikely to benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options and outcomes for patients with triple negative breast cancer.
How similar studies have performed: Other research has shown promising results in targeting the Hedgehog pathway in cancer treatment, indicating that this approach may hold significant potential.
Where this research is happening
MAYAGUEZ, UNITED STATES
- UNIVERSITY OF PUERTO RICO MAYAGUEZ — MAYAGUEZ, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DOMENECH, MARIBELLA — UNIVERSITY OF PUERTO RICO MAYAGUEZ
- Study coordinator: DOMENECH, MARIBELLA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.