Investigating how specific cell signaling affects lung cell regeneration and diseases.
VEGF/KDR Signaling in Airway Epithelial Regeneration and Disease
This study is looking at how certain signals in the lungs help repair airway cells, which could lead to better treatments for people with asthma and COPD by understanding how these signals affect mucus production and breathing.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10811632 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of VEGF/KDR signaling in the regeneration of airway epithelial cells and its implications in lung diseases such as asthma and COPD. By analyzing different subpopulations of club cells, which are crucial for airway health, the study aims to uncover the cellular and molecular mechanisms that lead to mucous metaplasia, a condition associated with various lung diseases. The researchers will utilize advanced techniques like single-cell RNA sequencing to identify how changes in signaling pathways affect cell differentiation and contribute to airway obstruction. This knowledge could lead to new therapeutic strategies for patients suffering from respiratory conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with asthma, COPD, or other respiratory conditions characterized by mucous metaplasia.
Not a fit: Patients with non-respiratory conditions or those without airway obstruction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients with asthma and other lung diseases by targeting the underlying mechanisms of airway obstruction.
How similar studies have performed: Previous research has shown promising results in understanding cell signaling pathways in lung diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Que, Jianwen — Columbia University Health Sciences
- Study coordinator: Que, Jianwen
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.