Investigating how specific brain receptors affect itch sensation
Role of NK-1 receptors in descending modulation and ascending transmission of itch
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA AT DAVIS · NIH-10897239
This study is looking at how certain receptors in the brain and spinal cord affect itching, especially for people with conditions like atopic dermatitis and psoriasis, to find better ways to help those who suffer from chronic itch.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA AT DAVIS (nih funded) |
| Locations | 1 site (DAVIS, UNITED STATES) |
| Trial ID | NIH-10897239 on ClinicalTrials.gov |
What this research studies
This research explores the role of NK-1 receptors in the brain and spinal cord in regulating itch sensations, particularly in conditions like atopic dermatitis and psoriasis. By using advanced techniques such as chemogenetics and optogenetics, the study aims to understand how these receptors can inhibit or transmit itch signals. The research involves testing these mechanisms in mouse models to identify potential new treatments for chronic itch, which affects many patients and is often poorly managed.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals suffering from chronic itch conditions such as atopic dermatitis or psoriasis.
Not a fit: Patients with acute itch not related to chronic skin conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for chronic itch, improving the quality of life for many patients.
How similar studies have performed: Previous research has shown promise in targeting similar receptors for itch modulation, indicating potential for success in this approach.
Where this research is happening
DAVIS, UNITED STATES
- UNIVERSITY OF CALIFORNIA AT DAVIS — DAVIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CARSTENS, EARL E — UNIVERSITY OF CALIFORNIA AT DAVIS
- Study coordinator: CARSTENS, EARL E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.