Investigating how specific brain receptors affect alcohol abuse
GABA-A receptor subtype mechanisms and the abuse-related effects of alcohol
This study is looking at how alcohol affects the brain and how certain brain receptors might play a role in addiction, with the goal of finding better treatments for people struggling with alcohol dependence.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Mississippi Med Ctr NIH-funded |
| Lab location | 1 site (Jackson, United States) |
| Project ID | NIH-10897182 on NIH RePORTER |
What this research studies
This research explores the mechanisms by which alcohol affects the brain, particularly focusing on GABA-A receptors, which are involved in alcohol's reinforcing and relapse-inducing effects. Using animal models, the study will assess how different subtypes of these receptors contribute to the experience of alcohol consumption and its addictive properties. By employing selective compounds that target specific receptor subtypes, the research aims to uncover potential therapeutic strategies for treating alcohol dependence. The findings could lead to more effective treatments tailored to individual patients based on their neurobiological responses to alcohol.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals struggling with alcohol dependence or those at risk of developing alcohol-related disorders.
Not a fit: Patients who do not consume alcohol or have no history of alcohol abuse may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of targeted therapies that reduce alcohol abuse and dependence.
How similar studies have performed: Previous research has shown promise in targeting specific receptor subtypes for addiction treatment, indicating that this approach could yield significant insights.
Where this research is happening
Jackson, United States
- University of Mississippi Med Ctr — Jackson, United States (Active)
Researchers
- Principal investigator: Platt, Donna M — University of Mississippi Med Ctr
- Study coordinator: Platt, Donna M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.