Investigating how specific brain neurons influence food intake.
Official title: How NTS NPY neurons alter NTS circuitry to promote food intake
Funded at Washington State University · NIH-11061346 · Data updated 2026-11-12
This study is looking at how certain brain cells help control how much we eat and feel hungry, which could lead to new ways to tackle obesity and related health problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington State University NIH-funded |
| Lab location | 1 site (Pullman, United States) |
| Project start | April 1, 2024 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $462,801 |
| NIH project number | 5R01DK138673-02 |
| Project ID | NIH-11061346 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals struggling with obesity or related metabolic conditions who are interested in understanding the biological mechanisms of appetite regulation.
✕Less likely to help
Patients who are not affected by obesity or metabolic disorders may not benefit from this research.
What this research studies
This research focuses on understanding the role of a specific group of neurons in the brainstem that are involved in regulating food intake. By examining how these neurons interact with other brain circuits, the study aims to uncover mechanisms that control meal size and appetite. The researchers will use advanced techniques to manipulate and observe the activity of these neurons in response to various stimuli, providing insights into their function in hunger and satiety. This could lead to new strategies for addressing obesity and related health issues.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for obesity and related metabolic disorders by targeting specific brain pathways that regulate appetite.
How similar studies have gone: Previous research has shown promising results in understanding the brain's role in appetite regulation, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Washington State University
Pullman, United States Active
Researchers
- Principal investigator: Appleyard, Suzanne M — Washington State University
- Study coordinator: Appleyard, Suzanne M
Related research
Other NIH-funded projects on the same topics.
-
Center for Research in Emerging Infectious Diseases in East and Central Africa Plus
A center-led effort to study and respond to emerging infectious diseases in East and Central Africa, with collaboration in the region and Central America.
-
Center for Research in Emerging Infectious Diseases in East and Central Africa Plus
A national/international research center works to understand and respond to emerging infectious diseases in East and Central Africa, with implications for global health.
-
Surveillance and preparedness for flu and other respiratory pathogens in Kenya
A US-based research grant aims to improve how Kenya detects and prepares for influenza and other respiratory diseases to protect people there and global health.
-
How pre-existing anti-staphylococcal antibodies and B cells can affect vaccines
A study at Washington State University will explore why antibodies and B cells from prior Staphylococcus aureus exposure may weaken or alter responses to vaccines against SA.
-
Music-based, real-time stress relief to support early alcohol recovery
A new mobile program uses just-in-time music listening to help adults in the first 90 days after detox reduce stress and support recovery from alcohol use disorder.
-
Promoting Indigenous Wellness Through Community-Lent Healing and Knowledge
A Native-serving research program collaborates with Indigenous communities to improve wellbeing and relieve harm from opioids and pain by using local strengths and culturally-led approaches.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.