Investigating how specific brain neurons affect body weight regulation
Official title: The Role of IRX3 Neurons in the Regulation of Body Weight Homeostasis
Funded at University of Iowa · NIH-10874445 · Data updated 2026-11-12
This study is looking at how certain brain cells help control weight and energy in the body, especially for people dealing with obesity, using a special mouse model that reflects a human gene linked to weight gain, with hopes of finding new ways to treat obesity.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Iowa NIH-funded |
| Lab location | 1 site (Iowa City, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $35,771 |
| NIH project number | 5F31DK137587-02 |
| Project ID | NIH-10874445 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would include individuals struggling with obesity or related metabolic disorders.
✕Less likely to help
Patients who are not affected by obesity or do not have metabolic disorders may not receive direct benefits from this research.
What this research studies
This research explores the role of IRX3 neurons in managing body weight and energy balance, particularly in the context of obesity. By utilizing a novel mouse model that mimics a human genetic variant associated with obesity, the study aims to uncover the mechanisms through which these neurons influence body weight homeostasis. The research employs advanced techniques such as electrophysiology and genetic analysis to understand the connections between these neurons and obesity-related genetic factors. Patients may benefit from insights gained into the biological underpinnings of obesity, potentially leading to new treatment strategies.
Why it matters
Potential benefit: If successful, this research could lead to new approaches for preventing and treating obesity by targeting specific brain mechanisms.
How similar studies have gone: Previous research has shown promising results in understanding genetic factors related to obesity, but the specific focus on IRX3 neurons is relatively novel.
Where this research is happening
-
University of Iowa
Iowa City, United States Active
Researchers
- Principal investigator: Sullivan, Andrew — University of Iowa
- Study coordinator: Sullivan, Andrew
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.