Investigating how specific brain cells contribute to opioid addiction in rodents
Single-Cell Dissection of Ensembles and Cell Types Mediating Opioid Action in the Rodent Brain
['FUNDING_R01'] · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · NIH-11034063
This study is looking at how certain brain cells and genes are involved in opioid addiction in rodents, with the hope of finding new ways to help people struggling with opioid use disorder.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (nih funded) |
| Locations | 1 site (CAMBRIDGE, UNITED STATES) |
| Trial ID | NIH-11034063 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the cellular and genetic mechanisms behind opioid addiction by examining specific brain regions in rodents. Using advanced transcriptomic techniques, the study will analyze the genes and pathways involved in opioid action, particularly in areas of the brain associated with reward and addiction. By identifying the cell types and genetic factors that contribute to opioid use disorder, the research aims to uncover potential targets for new treatments. The findings could lead to a better understanding of how addiction develops and how it can be treated effectively.
Who could benefit from this research
Good fit: Ideal candidates for benefiting from this research include individuals struggling with opioid use disorder or those at risk of developing addiction.
Not a fit: Patients who do not have a history of substance use or are not affected by opioid addiction may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating opioid addiction and improving patient outcomes.
How similar studies have performed: Previous research has shown promising results in understanding addiction mechanisms through similar cellular and genetic approaches, indicating potential for success in this study.
Where this research is happening
CAMBRIDGE, UNITED STATES
- MASSACHUSETTS INSTITUTE OF TECHNOLOGY — CAMBRIDGE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HEIMAN, MYRIAM — MASSACHUSETTS INSTITUTE OF TECHNOLOGY
- Study coordinator: HEIMAN, MYRIAM
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: addictive disorder