Investigating how specific brain cells contribute to early brain dysfunction in autism
Role of local interneurons in early cortical dysfunction in Shank3 KO mice
This study is looking at how certain brain cells in mice, which are linked to autism, behave during early development to see if changes in their activity might explain why some kids with autism also have epilepsy.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-10741946 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of local interneurons in the brain of mice with a genetic deletion linked to autism. By examining the electrical activity and behavior of these cells during early development, the study aims to uncover how disruptions in these neurons may lead to increased brain activity associated with epilepsy and autism. The researchers will utilize advanced techniques like whole-cell electrophysiology and 2-photon microscopy to gather detailed information about the functioning of these interneurons. This work could provide insights into the mechanisms of cortical hyperactivity and its implications for autism spectrum disorders.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals with autism spectrum disorders, particularly those experiencing epilepsy or related symptoms.
Not a fit: Patients without autism spectrum disorders or epilepsy may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for managing epilepsy and autism by targeting specific brain cell dysfunctions.
How similar studies have performed: Previous research has indicated that targeting interneuron dysfunction can lead to significant advancements in understanding and treating epilepsy and autism, suggesting a promising avenue for this study.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Peixoto, Rui — University of Pittsburgh at Pittsburgh
- Study coordinator: Peixoto, Rui
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.