Investigating how specific antibodies work during Shigella infections
Functional profiling of OSP-specific and other antibodies during shigella infection
['FUNDING_R01'] · MASSACHUSETTS GENERAL HOSPITAL · NIH-10904882
This study is looking at how certain antibodies help protect young children from Shigella infections, which cause diarrhea, especially in places with fewer resources, and it involves comparing the immune responses of both children and adults to find out what works best.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MASSACHUSETTS GENERAL HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10904882 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of antibodies in protecting against Shigella infections, which are a major cause of diarrhea in young children, particularly in low-resource settings. The study will analyze how different types of antibodies, especially those targeting O-specific polysaccharides, function and their effectiveness in providing protection. By examining antibody responses in both young children and adults, the research aims to identify key factors that contribute to successful immune responses. The approach includes a household contact study in Dhaka, Bangladesh, complemented by data from North American vaccine studies.
Who could benefit from this research
Good fit: Ideal candidates for this research include young children and adults who are at risk of Shigella infections, particularly those living in resource-limited settings.
Not a fit: Patients who are not at risk for Shigella infections or those who have already been vaccinated against it may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved vaccines and treatments for Shigella infections, significantly reducing illness and mortality in affected populations.
How similar studies have performed: Previous research has shown that understanding antibody functions can lead to breakthroughs in vaccine development, indicating that this approach has potential for success.
Where this research is happening
BOSTON, UNITED STATES
- MASSACHUSETTS GENERAL HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: RYAN, EDWARD T. — MASSACHUSETTS GENERAL HOSPITAL
- Study coordinator: RYAN, EDWARD T.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.