Investigating how specific antibodies contribute to multiple sclerosis
Official title: Contribution of antibodies targeting PLP1-anchored membrane domains to multiple sclerosis pathogenesis
Funded at University of Colorado Denver · NIH-10981025 · Data updated 2026-11-12
This study is looking at how certain immune cells and the antibodies they make might play a role in multiple sclerosis, and it’s for people with MS who want to understand more about how their condition affects their nerves and what new treatments might be on the horizon.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project start | September 5, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $405,282 |
| NIH project number | 1R01NS130100-01A1 |
| Project ID | NIH-10981025 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with multiple sclerosis, particularly those with active disease.
✕Less likely to help
Patients with other neurological disorders or those without a diagnosis of multiple sclerosis may not benefit from this research.
What this research studies
This research focuses on understanding the role of B-cells and the antibodies they produce in the development of multiple sclerosis (MS). By analyzing antibodies from patients with MS, researchers aim to identify how these antibodies interact with myelin and contribute to nerve damage. The study employs advanced techniques to produce and test recombinant antibodies, which mimic those found in patients, to explore their effects on oligodendrocytes, the cells responsible for myelin maintenance. The findings could provide insights into the mechanisms of MS and potential therapeutic targets.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that specifically target the harmful antibodies involved in multiple sclerosis.
How similar studies have gone: Previous studies have shown promising results in understanding the role of B-cells in multiple sclerosis, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Colorado Denver
Aurora, United States Active
Researchers
- Principal investigator: Bennett, Jeffrey L — University of Colorado Denver
- Study coordinator: Bennett, Jeffrey L
Related research
Other NIH-funded projects on the same topics.
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A short-term study aims to test MRI biomarkers that could help diagnose and predict MS in patients, using advanced imaging techniques.
-
Mediterranean-style eating and aging in people with multiple sclerosis
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A new MRI-based method will non-invasively measure how the brain uses glucose and ketones in people with multiple sclerosis.
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Astrocyte exosomes as aging biomarkers and drivers of MS progression
Researchers are testing a blood-based biomarker from astrocyte-like exosomes to understand why multiple sclerosis gets worse with age and to identify potential targets for treatment.
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Promoting brain repair in MS with a natural compound that nudges neural stem cells
A researcher is testing a natural-product–based compound that may help people with multiple sclerosis repair nerve damage by guiding brain stem cells to become neurons and myelin-producing cells.
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Targeted B cell tolerance therapy for multiple sclerosis using Ace-DEX microparticles
A new therapy using tiny biopolymer particles given through the vein aims to retrain B cells to tolerate the immune system in people with multiple sclerosis.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.