Investigating how special molecules in bone marrow help resolve inflammation
Official title: Bone Marrow Functions of Novel Pro-Resolving Mediators
Funded at Yale University · NIH-10896313 · Data updated 2026-11-12
This study is looking at how certain natural substances in the bone marrow help manage inflammation and support the production of blood cells, which could lead to better treatments for people with blood-related issues.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $248,984 |
| NIH project number | 5R00HL153673-04 |
| Project ID | NIH-10896313 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research are individuals with conditions related to blood cell production or inflammatory diseases.
✕Less likely to help
Patients with stable, non-inflammatory conditions or those not affected by blood cell production issues may not receive any benefit from this research.
What this research studies
This research focuses on understanding the role of specialized pro-resolving mediators (SPMs) in bone marrow, particularly how they influence hematopoietic stem cells and progenitors (HSPCs) during inflammation. The study utilizes advanced metabololipidomics profiling to identify specific SPMs that are produced in the bone marrow under low oxygen conditions. By examining how these mediators promote the resolution of inflammation and enhance the production of blood cells, the research aims to uncover new therapeutic targets for blood-related diseases. Patients may benefit from insights that could lead to improved treatments for conditions involving inflammation and blood cell production.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that enhance the body's ability to resolve inflammation and improve blood cell production.
How similar studies have gone: Other research has shown promising results with similar approaches in understanding the role of mediators in inflammation, suggesting potential for success in this area.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Libreros, Stephania — Yale University
- Study coordinator: Libreros, Stephania
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.