Investigating how Sox10 influences neuron development in the gut
Official title: Assessing Sox 10's effect on chromatin accessibility in enteric neuron lineage diversification
Funded at Vanderbilt University · NIH-10948897 · Data updated 2026-11-12
This study is looking at how a specific gene called Sox10 helps develop important nerve cells in the gut, which could help us understand conditions like Hirschsprung’s disease and gastroesophageal reflux, so we can learn more about how to improve gut health.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University NIH-funded |
| Lab location | 1 site (Nashville, UNITED STATES) |
| Project start | July 1, 2023 |
| Project end | June 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $34,250 |
| NIH project number | 5F31DK137637-02 |
| Project ID | NIH-10948897 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals under 21 years old with conditions like Hirschsprung’s disease or other enteric nervous system disorders.
✕Less likely to help
Patients with fully developed enteric nervous systems or those over 21 years old may not benefit from this research.
What this research studies
This research explores the role of the Sox10 gene in the development of enteric neurons, which are crucial for gut function. By examining how Sox10 affects chromatin accessibility, the study aims to understand the genetic factors that lead to conditions like Hirschsprung’s disease and gastroesophageal reflux. The researchers will use advanced techniques such as ATAC sequencing to analyze changes in gene expression and neuron differentiation. This work could provide insights into the underlying mechanisms of enteric nervous system disorders.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and potential treatments for gastrointestinal disorders linked to enteric neuron development.
How similar studies have gone: Previous research has shown promising results in understanding genetic factors affecting enteric neuron development, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Vanderbilt University
Nashville, United States Active
Researchers
- Principal investigator: Benthal, Joseph T — Vanderbilt University
- Study coordinator: Benthal, Joseph T
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.