Investigating how solutes move in the brain of Alzheimer's patients
Measuring impairment of extracellular solute transport in Alzheimer's disease
This study is looking at how important substances move around in the brain and how this process is affected by Alzheimer's disease, using mice to help us understand what happens when the brain changes due to amyloid plaques, which could lead to new ways to help people with Alzheimer's.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-10511544 on NIH RePORTER |
What this research studies
This research focuses on understanding how solutes, which are essential for brain function, are transported in the extracellular space of the brain, particularly in the context of Alzheimer's disease. Using advanced imaging techniques, the study will measure the rates and mechanisms of solute transport in mouse models of Alzheimer's. By examining the changes in the brain's structure and function due to amyloid plaques, the research aims to uncover how these changes affect nutrient delivery and waste clearance in the brain. This could provide insights into the underlying mechanisms of Alzheimer's disease and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those at risk of developing it.
Not a fit: Patients with other types of dementia or neurological disorders unrelated to Alzheimer's may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for enhancing brain health and developing treatments for Alzheimer's disease.
How similar studies have performed: Other research has shown promise in understanding solute transport in the brain, but this specific approach using advanced imaging techniques in Alzheimer's models is relatively novel.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Smith, Alexander James — University of California, San Francisco
- Study coordinator: Smith, Alexander James
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.