Investigating how SMARCB1 affects tumor formation in malignant rhabdoid tumors in children
SMARCB1 regulated SWI/SNF complex function in Malignant Rhabdoid Tumors
This study is looking at how changes in the SMARCB1 gene might cause a rare and aggressive cancer called malignant rhabdoid tumors in children, with the hope of finding new ways to treat this illness.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Dartmouth College NIH-funded |
| Lab location | 1 site (Hanover, United States) |
| Project ID | NIH-11056868 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of the SMARCB1 gene in malignant rhabdoid tumors, a rare and aggressive form of cancer primarily affecting children. Researchers will explore how mutations in the SMARCB1 gene disrupt the function of the SWI/SNF chromatin remodeling complex, which is crucial for regulating gene expression and maintaining normal cell function. By using advanced genetic models, the study aims to uncover the mechanisms by which these mutations contribute to tumor development and progression, potentially leading to new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are children diagnosed with malignant rhabdoid tumors, particularly those under the age of 11.
Not a fit: Patients with other types of cancers or those without SMARCB1 mutations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for children with malignant rhabdoid tumors.
How similar studies have performed: Other research has shown promising results in understanding chromatin remodeling complexes in cancer, suggesting that this approach could yield valuable insights.
Where this research is happening
Hanover, United States
- Dartmouth College — Hanover, United States (Active)
Researchers
- Principal investigator: Wang, Xiaofeng — Dartmouth College
- Study coordinator: Wang, Xiaofeng
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.