Investigating how small vessel disease affects brain degeneration in Alzheimer's disease
Small vessel disease contributions to neurodegeneration in Alzheimer's disease
This study is looking at how small vessel disease and Alzheimer's disease affect brain health and memory in older adults, using brain scans and tissue samples to see how inflammation and other factors play a role.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rush University Medical Center NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-10889217 on NIH RePORTER |
What this research studies
This research explores the relationship between small vessel disease (SVD) and Alzheimer's disease (AD) to understand how they contribute to brain atrophy, particularly in areas critical for memory and cognition. By analyzing brain tissue and MRI scans, the study aims to identify how inflammation and other biological processes influence brain health in older adults. The research integrates data from multiple community studies to provide a comprehensive view of the interplay between these conditions. Patients may undergo neuroimaging and cognitive assessments as part of the research.
Who could benefit from this research
Good fit: Ideal candidates for this research include older adults diagnosed with Alzheimer's disease, especially those with comorbid small vessel disease.
Not a fit: Patients without Alzheimer's disease or significant small vessel disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment strategies for Alzheimer's disease, particularly in populations affected by small vessel disease.
How similar studies have performed: Previous research has shown promising results in understanding the relationship between small vessel disease and neurodegeneration, indicating that this approach has potential for significant findings.
Where this research is happening
Chicago, United States
- Rush University Medical Center — Chicago, United States (Active)
Researchers
- Principal investigator: Kapasi, Alifiya — Rush University Medical Center
- Study coordinator: Kapasi, Alifiya
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.