Investigating how small RNAs from viruses interact with human cells
Official title: Small RNA-mediated warfare between viruses and their hosts
Funded at Icahn School of Medicine at Mount Sinai · NIH-10931371 · Data updated 2026-11-12
This study is looking at tiny molecules made by viruses, like the one that causes COVID-19, to see how they affect our cells and might help us find better ways to treat viral infections.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 20, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $422,500 |
| NIH project number | 5R35GM150649-02 |
| Project ID | NIH-10931371 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals affected by COVID-19 or those at risk of severe outcomes from viral infections.
✕Less likely to help
Patients with viral infections not related to coronaviruses may not benefit from this research.
What this research studies
This research explores the role of non-coding RNAs (ncRNAs) produced by viruses, particularly focusing on how these small RNAs influence both viral and host cellular processes. The study aims to understand the mechanisms by which viral ncRNAs, such as those from SARS-CoV-2, affect human cell functions and contribute to diseases like COVID-19. By examining two specific classes of viral ncRNAs, the research seeks to uncover their potential roles in disease progression and treatment. The findings could lead to new therapeutic strategies for managing viral infections.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments for viral infections, including COVID-19.
How similar studies have gone: Previous research has shown promise in understanding viral ncRNAs, indicating potential for success in this area.
Where this research is happening
-
Icahn School of Medicine at Mount Sinai
New York, United States Active
Researchers
- Principal investigator: Pawlica, Paulina — Icahn School of Medicine at Mount Sinai
- Study coordinator: Pawlica, Paulina
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.