Investigating how small proteins regulate mitochondrial function in heart health.
Microprotein Regulation of Mitochondrial Function
['FUNDING_R01'] · CINCINNATI CHILDRENS HOSP MED CTR · NIH-10980541
This study is looking at tiny proteins that might help improve how heart cells produce energy, with the hope of finding new ways to treat heart failure and make hearts work better for patients.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CINCINNATI CHILDRENS HOSP MED CTR (nih funded) |
| Locations | 1 site (CINCINNATI, UNITED STATES) |
| Trial ID | NIH-10980541 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of microproteins in regulating mitochondrial function, particularly in the context of heart failure. By exploring how these small proteins influence energy production and metabolism in heart cells, the study aims to identify new therapeutic targets that could improve heart function. The approach combines computational analysis and experimental techniques to uncover the molecular mechanisms by which microproteins affect cardiac health. Patients may benefit from insights that could lead to innovative treatments addressing the underlying causes of heart failure rather than just alleviating symptoms.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with heart failure or related cardiac conditions.
Not a fit: Patients with non-cardiac related health issues or those without heart failure may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that restore heart function by targeting mitochondrial dysfunction in heart failure patients.
How similar studies have performed: While the role of microproteins in mitochondrial function is a relatively novel area of investigation, preliminary studies have shown promising results in understanding their regulatory roles.
Where this research is happening
CINCINNATI, UNITED STATES
- CINCINNATI CHILDRENS HOSP MED CTR — CINCINNATI, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MAKAREWICH, CATHERINE A — CINCINNATI CHILDRENS HOSP MED CTR
- Study coordinator: MAKAREWICH, CATHERINE A
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.