Investigating how small open reading frames in untranslated regions affect protein translation
Translation of small open reading frames in 3'UTR enhances translation of canonical open reading frames
['FUNDING_OTHER'] · ROCKEFELLER UNIVERSITY · NIH-10894163
This study is looking at tiny parts of genes that might help make proteins, especially in cancer, to find out how they work and how changes in gene activity could lead to new treatments for patients.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ROCKEFELLER UNIVERSITY (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-10894163 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of small open reading frames (ORFs) found in untranslated regions (UTRs) of genes, particularly how they influence the translation of canonical open reading frames. By using advanced techniques like ribosome profiling, the study aims to dissect the mechanisms by which these small ORFs enhance protein production, especially in the context of cancer. The research will also explore how changes in gene regulation, such as alternative polyadenylation, may contribute to cancer development. Patients may benefit from insights gained into these processes, potentially leading to new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with cancer or those at risk for developing cancer due to genetic factors.
Not a fit: Patients with non-cancerous conditions or those not affected by genetic factors related to translation regulation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into cancer biology and novel therapeutic approaches for treating cancer.
How similar studies have performed: While the exploration of small ORFs is a relatively novel area, preliminary findings suggest that similar approaches have shown promise in understanding gene regulation in other contexts.
Where this research is happening
NEW YORK, UNITED STATES
- ROCKEFELLER UNIVERSITY — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WU, QIUSHUANG — ROCKEFELLER UNIVERSITY
- Study coordinator: WU, QIUSHUANG
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancer Biology, Cancer Cause