Investigating how sleep problems relate to anxiety in Alzheimer's disease
Sleep Impairment: A Mechanism Explaining Neuropsychiatric Symptoms in Alzheimer's
This study is looking at how sleep problems and anxiety are connected in people with Alzheimer's disease, especially focusing on how a protein called beta-amyloid affects their sleep, to help find better ways to support their well-being.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Berkeley NIH-funded |
| Lab location | 1 site (Berkeley, United States) |
| Project ID | NIH-11080263 on NIH RePORTER |
What this research studies
This research explores the connection between sleep disturbances and anxiety in individuals with Alzheimer's disease. It aims to understand how the accumulation of beta-amyloid, a protein associated with Alzheimer's, affects sleep patterns, particularly non-rapid eye movement (NREM) sleep. By examining these relationships, the study seeks to uncover the underlying mechanisms that link sleep impairment to increased anxiety, potentially leading to new treatment strategies. Patients may be monitored for changes in sleep and anxiety levels over time to assess the impact of Alzheimer's pathology.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease who experience sleep disturbances and anxiety.
Not a fit: Patients without a diagnosis of Alzheimer's disease or those who do not experience sleep or anxiety issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic approaches that improve sleep and reduce anxiety in Alzheimer's patients, potentially slowing cognitive decline.
How similar studies have performed: Previous research has indicated that addressing sleep issues can positively impact anxiety and cognitive function in Alzheimer's patients, suggesting a promising avenue for this investigation.
Where this research is happening
Berkeley, United States
- University of California Berkeley — Berkeley, United States (Active)
Researchers
- Principal investigator: Walker, Matthew P — University of California Berkeley
- Study coordinator: Walker, Matthew P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.