Investigating how sleep problems affect emotional regulation in Alzheimer's patients
Official title: Sleep Disturbance and Emotion Regulation Brain Dysfunction as Mechanisms of Neuropsychiatric Symptoms in Alzheimer's Dementia
Funded at Stanford University · NIH-11062801 · Data updated 2026-11-12
This study is looking at how sleep problems might affect feelings of anxiety and restlessness in people with mild cognitive impairment and mild Alzheimer's Disease, and it will help us see if improving sleep through therapy can make these feelings better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | September 20, 2019 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $98,828 |
| NIH project number | 3R01MH120776-05S1 |
| Project ID | NIH-11062801 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with mild cognitive impairment or mild Alzheimer's Disease who are experiencing sleep disturbances and emotional distress.
✕Less likely to help
Patients with advanced Alzheimer's Disease or those without sleep disturbances may not benefit from this research.
What this research studies
This research explores the connection between sleep disturbances and neuropsychiatric symptoms such as anxiety and agitation in patients with mild cognitive impairment and mild Alzheimer's Disease. By examining how sleep affects brain function related to emotion regulation, the study aims to understand the underlying mechanisms that contribute to these symptoms. Participants will be involved in a randomized controlled trial where they will receive either Cognitive Behavioral Therapy for Insomnia or a control treatment to assess the impact of improved sleep on emotional and behavioral symptoms.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for managing emotional distress in Alzheimer's patients through better sleep management.
How similar studies have gone: Previous research has shown promising results in using cognitive behavioral therapy to improve sleep and emotional regulation in various populations, suggesting potential success in this approach for Alzheimer's patients.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Goldstein-Piekarski, Andrea — Stanford University
- Study coordinator: Goldstein-Piekarski, Andrea
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Investigating how sleep issues affect emotional regulation in Alzheimer's patients
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.