Investigating how sleep patterns affect insulin resistance in adolescents
Examining a mechanism for insulin resistance in short sleeping adolescents: Melatonin, food intake, and the role of a melatonin receptor gene variant (MTNR1B)
['FUNDING_R03'] · UNIVERSITY OF COLORADO DENVER · NIH-10701803
This study is looking at how not getting enough sleep and eating at the wrong times might affect how well young people, especially those who are overweight, process sugar in their bodies, and it will also check if a certain gene related to sleep affects this.
Quick facts
| Phase | ['FUNDING_R03'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF COLORADO DENVER (nih funded) |
| Locations | 1 site (Aurora, UNITED STATES) |
| Trial ID | NIH-10701803 on ClinicalTrials.gov |
What this research studies
This research explores the connection between insufficient sleep, circadian misalignment, and insulin resistance in adolescents. It focuses on how the timing of food intake and melatonin levels may influence metabolic health, particularly in those who are overweight. By examining a specific gene variant related to melatonin receptors, the study aims to understand its impact on insulin sensitivity in young people. The research may involve dietary assessments and sleep pattern evaluations to identify potential interventions.
Who could benefit from this research
Good fit: Ideal candidates for this research are adolescents aged 12-20 who experience insufficient sleep and may be at risk for obesity or metabolic disorders.
Not a fit: Patients who have normal sleep patterns and metabolic health are unlikely to benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing type 2 diabetes in adolescents by promoting better sleep and eating habits.
How similar studies have performed: Previous research has indicated that improving sleep and aligning circadian rhythms can positively affect metabolic health, suggesting potential success for this approach.
Where this research is happening
Aurora, UNITED STATES
- UNIVERSITY OF COLORADO DENVER — Aurora, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SIMON, STACEY LYNN — UNIVERSITY OF COLORADO DENVER
- Study coordinator: SIMON, STACEY LYNN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.