Investigating how sleep issues affect emotional regulation in Alzheimer's patients
Sleep Disturbance and Emotion Regulation Brain Dysfunction as Mechanisms of Neuropsychiatric Symptoms in Alzheimer's Dementia
This study is looking at how sleep problems might affect feelings of anxiety and depression in people with mild cognitive impairment and mild Alzheimer's disease, and it will see if better sleep can help improve these feelings by offering therapy for insomnia to some participants.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-10889906 on NIH RePORTER |
What this research studies
This research explores the connection between sleep disturbances and neuropsychiatric symptoms such as anxiety and depression in patients with mild cognitive impairment and mild Alzheimer's disease. By examining how sleep affects brain function related to emotion regulation, the study aims to understand if improving sleep can alleviate these symptoms. Participants will be involved in a randomized controlled trial where they will receive either Cognitive Behavioral Therapy for Insomnia or a control treatment, allowing researchers to assess the impact of sleep manipulation on emotional and behavioral outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with mild cognitive impairment or mild Alzheimer's disease who are experiencing sleep disturbances and emotional distress.
Not a fit: Patients with severe Alzheimer's disease or those without sleep disturbances may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved emotional well-being and reduced neuropsychiatric symptoms in Alzheimer's patients through better sleep management.
How similar studies have performed: Previous research has shown promising results in using sleep interventions to improve emotional regulation in various populations, suggesting potential success for this approach in Alzheimer's patients.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Goldstein-Piekarski, Andrea — Stanford University
- Study coordinator: Goldstein-Piekarski, Andrea
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.