Investigating how sleep interventions may slow Alzheimer's disease progression
Evaluating the disease-modifying potential of a sleep intervention for Alzheimer's Disease outcomes
This study is looking at whether improving sleep with melatonin can help slow down Alzheimer's disease and its effects on memory and thinking in older adults.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Iowa NIH-funded |
| Lab location | 1 site (Iowa City, United States) |
| Project ID | NIH-10574544 on NIH RePORTER |
What this research studies
This research explores the potential of sleep interventions, particularly melatonin, to modify the progression of Alzheimer's disease (AD). It examines the relationship between sleep disruptions and the accumulation of amyloid beta, a key factor in AD pathology. By utilizing experimental studies, the research aims to determine if improving sleep can positively impact cognitive outcomes and biomarkers associated with Alzheimer's. The study is designed to gather evidence that could lead to effective treatments for older adults experiencing cognitive decline.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults diagnosed with mild cognitive impairment or early-stage Alzheimer's disease.
Not a fit: Patients with advanced Alzheimer's disease or those who do not experience sleep disturbances may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options that slow the progression of Alzheimer's disease and improve the quality of life for patients.
How similar studies have performed: Previous studies have shown promising results with sleep interventions in animal models and smaller human studies, indicating potential for success in this approach.
Where this research is happening
Iowa City, United States
- University of Iowa — Iowa City, United States (Active)
Researchers
- Principal investigator: Denburg, Natalie L — University of Iowa
- Study coordinator: Denburg, Natalie L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.