Investigating how sleep disturbances relate to Alzheimer's disease through a specific brain region.
Thalamic Reticular Nucleus Dysfunction in Alzheimer's Disease
['FUNDING_R01'] · BAYLOR COLLEGE OF MEDICINE · NIH-10827862
This study is looking at how a part of the brain called the thalamic reticular nucleus might be causing sleep problems in people with Alzheimer's disease, and by understanding this, the researchers hope to find new ways to help improve sleep and thinking skills for those affected.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BAYLOR COLLEGE OF MEDICINE (nih funded) |
| Locations | 1 site (HOUSTON, UNITED STATES) |
| Trial ID | NIH-10827862 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of the thalamic reticular nucleus (TRN) in Alzheimer's disease (AD) and how its dysfunction may contribute to sleep disturbances commonly seen in patients. By examining both human and animal models, the study aims to uncover the mechanisms behind these sleep issues and their impact on disease progression. The researchers will analyze brain activity patterns and the levels of key proteins associated with AD, such as Aβ and tau, to identify potential therapeutic targets. This work could lead to new strategies for improving sleep and cognitive function in individuals with Alzheimer's.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Alzheimer's disease who experience sleep disturbances.
Not a fit: Patients with Alzheimer's disease who do not have sleep disturbances may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for sleep disturbances in Alzheimer's patients, potentially slowing disease progression.
How similar studies have performed: Previous research has shown that targeting sleep disturbances can have positive effects on cognitive function in Alzheimer's patients, suggesting a promising avenue for this investigation.
Where this research is happening
HOUSTON, UNITED STATES
- BAYLOR COLLEGE OF MEDICINE — HOUSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHIN, JEANNIE — BAYLOR COLLEGE OF MEDICINE
- Study coordinator: CHIN, JEANNIE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease