Investigating how sleep disturbances may predict delirium and Alzheimer's disease after heart surgery
Sleep-Wake Disturbance as a Predictor of Delirium and Subsequent Alzheimer's Disease and Related Dementias after Surgical Aortic Valve Replacement
This study is looking at how sleep problems might affect the chances of developing confusion or Alzheimer's disease in older adults who are having heart valve surgery, and it aims to help doctors better care for these patients by tracking their sleep and thinking skills before and after the surgery.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-11035126 on NIH RePORTER |
What this research studies
This research focuses on understanding the connection between sleep-wake disturbances and the risk of developing delirium and Alzheimer's disease in patients undergoing surgical aortic valve replacement. By using actigraphy and home sleep tests, the study aims to objectively assess sleep patterns before surgery and their potential link to postoperative cognitive issues. The goal is to improve care for older adults by identifying those at higher risk for these conditions, ultimately enhancing clinical outcomes. Participants will be monitored over time to gather data on their sleep and cognitive health.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who are scheduled for surgical aortic valve replacement.
Not a fit: Patients who are not undergoing surgical aortic valve replacement or those with pre-existing severe cognitive impairment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better prevention strategies for delirium and Alzheimer's disease in at-risk patients.
How similar studies have performed: Previous research has shown promising results in linking sleep disturbances to cognitive decline, suggesting that this approach may yield valuable insights.
Where this research is happening
Rochester, United States
- University of Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Oldham, Mark Alan — University of Rochester
- Study coordinator: Oldham, Mark Alan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.