Investigating how sleep disruption after brain injuries may lead to Alzheimer's disease.
Defining the Role of Post-TBI Sleep Disruption in the Development of CTE and Alzheimer's Disease-Related Neuropathology
This study is looking at how sleep problems after a mild brain injury might be linked to changes in the brain that can lead to Alzheimer's disease, and it’s specifically for veterans who have experienced these injuries.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Seattle Inst for Biomedical/clinical Res NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-10523939 on NIH RePORTER |
What this research studies
This research explores the connection between sleep disturbances following mild traumatic brain injuries (mTBI) and the development of Alzheimer's disease-related changes in the brain. It aims to understand how these sleep issues may contribute to the accumulation of harmful proteins associated with Alzheimer's. The study will involve advanced imaging techniques to assess brain function and the clearance of these proteins during sleep. By examining veterans with a history of mTBI, the research seeks to uncover critical mechanisms that could inform future treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research are veterans over 45 years old who have experienced mild traumatic brain injuries.
Not a fit: Patients without a history of mild traumatic brain injuries or those under 45 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or delaying Alzheimer's disease in individuals with a history of brain injuries.
How similar studies have performed: Other research has indicated that sleep disturbances can influence neurodegenerative processes, suggesting that this approach may yield valuable insights.
Where this research is happening
Seattle, United States
- Seattle Inst for Biomedical/clinical Res — Seattle, United States (Active)
Researchers
- Principal investigator: Peskind, Elaine R. — Seattle Inst for Biomedical/clinical Res
- Study coordinator: Peskind, Elaine R.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.