Investigating how sleep apnea affects blood vessel health and aging
p16 Cellular Senescence and Vascular Dysfunction in Sleep Apnea
This study is looking at how obstructive sleep apnea affects your blood vessels and might make them age faster, while also checking out a protein called p16 that’s connected to this process, so if you have sleep apnea, your participation could help us understand how it impacts your heart health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kansas Medical Center NIH-funded |
| Lab location | 1 site (Kansas City, United States) |
| Project ID | NIH-11319450 on NIH RePORTER |
What this research studies
This research focuses on understanding the impact of obstructive sleep apnea (OSA) on blood vessel health and how it may accelerate biological aging. The study aims to explore the role of a specific protein, p16, which is linked to cellular aging and dysfunction in blood vessels. By examining the effects of intermittent hypoxia caused by OSA, the researchers hope to uncover the mechanisms behind vascular senescence and its implications for cardiovascular health. Patients may be involved in assessments that help identify the relationship between sleep apnea and vascular aging.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 years old who have been diagnosed with obstructive sleep apnea.
Not a fit: Patients without obstructive sleep apnea or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve vascular health and reduce cardiovascular risks for patients with sleep apnea.
How similar studies have performed: Previous research has shown promising results in targeting cellular senescence to improve health outcomes, suggesting potential for success in this novel approach.
Where this research is happening
Kansas City, United States
- University of Kansas Medical Center — Kansas City, United States (Active)
Researchers
- Principal investigator: Cortese, Rene Gabriel — University of Kansas Medical Center
- Study coordinator: Cortese, Rene Gabriel
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.