Investigating how skin and immune changes affect allergies in young children
Role of Skin Barrier and Immune Alterations in Allergic Sensitization
This study is looking at how changes in the skin and immune system might lead to allergies in kids under 11, especially by exploring how living on a farm and having a variety of germs around could help protect them from issues like eczema and food allergies.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-11075815 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of skin barrier and immune system changes in the development of allergic diseases, particularly in children under 11 years old. It examines how factors like a farming lifestyle and microbial diversity may protect against conditions like atopic dermatitis and food allergies. By studying different populations, including those in farming communities, the research aims to identify protective mechanisms that could lead to better prevention strategies for allergic diseases. The methodology includes advanced genetic sequencing techniques to analyze the microbiome and immune responses in young children.
Who could benefit from this research
Good fit: Ideal candidates for this research are children under 11 years old, particularly those with a family history of allergic diseases or atopic conditions.
Not a fit: Patients who are older than 11 years or do not have a history of allergic diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new prevention strategies for allergic diseases in children, potentially reducing the incidence of conditions like atopic dermatitis and food allergies.
How similar studies have performed: Previous research has shown promising results in understanding the protective effects of diverse microbiomes in farming communities, indicating that this approach has potential for success.
Where this research is happening
Rochester, United States
- University of Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Guttman, Emma — University of Rochester
- Study coordinator: Guttman, Emma
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.