Investigating how skeletal muscle affects blood vessel changes in lung disease
Role of Skeletal Muscle in Pulmonary Vascular Remodeling
This study is looking at how a protein called SIRT3 in your muscles might affect lung blood vessels in people with heart failure and pulmonary hypertension, with the hope of finding new ways to help treat this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project ID | NIH-10876896 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of skeletal muscle in pulmonary hypertension associated with heart failure, a condition that currently lacks effective treatments. The study examines how a specific protein, sirtuin-3 (SIRT3), which is found in lower levels in skeletal muscle, influences the production of signaling molecules that affect blood vessels in the lungs. By analyzing blood samples and muscle biopsies from patients, the researchers aim to uncover the mechanisms behind these changes and identify potential therapeutic targets. The approach includes advanced techniques like mass spectrometry to analyze proteins in the blood and muscle tissue.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with pulmonary hypertension associated with heart failure, particularly those with preserved ejection fraction.
Not a fit: Patients with pulmonary hypertension not related to heart failure or those without significant skeletal muscle involvement may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for pulmonary hypertension, improving outcomes for patients with heart failure.
How similar studies have performed: Previous research has shown promising results in understanding the role of skeletal muscle in cardiovascular conditions, suggesting that this approach may yield valuable insights.
Where this research is happening
Indianapolis, United States
- Indiana University Indianapolis — Indianapolis, United States (Active)
Researchers
- Principal investigator: Lai, Yen Chun Charly — Indiana University Indianapolis
- Study coordinator: Lai, Yen Chun Charly
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.