Investigating how SIRT3 deficiency affects metabolism in Alzheimer's disease patients.
SIRT3 Deficiency-mediated Metabolic Dysregulation in Comorbid Alzheimer's Disease
This study is looking at how a lack of a specific protein called SIRT3 might affect metabolism in people with Alzheimer's disease, especially since many of these individuals also have metabolic issues, and it hopes to find new ways to help treat the disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | VA Eastern Colorado Health Care System NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-10847321 on NIH RePORTER |
What this research studies
This research explores the relationship between SIRT3 deficiency and metabolic dysregulation in individuals with Alzheimer's disease (AD). It focuses on how metabolic syndrome, which often coexists with AD, can accelerate the progression of the disease. By examining the interactions between metabolic conditions and Alzheimer's, the study aims to identify common pathways that could inform treatment strategies. The research utilizes comorbid models to understand the impact of mitochondrial protein modifications on disease progression.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who are diagnosed with Alzheimer's disease and may also have metabolic syndrome.
Not a fit: Patients without Alzheimer's disease or those who do not have any metabolic conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment strategies that address both Alzheimer's disease and its associated metabolic conditions.
How similar studies have performed: Previous research has shown that targeting metabolic pathways can have significant effects on Alzheimer's disease progression, suggesting that this approach may yield valuable insights.
Where this research is happening
Aurora, UNITED STATES
- VA Eastern Colorado Health Care System — Aurora, United States (Active)
Researchers
- Principal investigator: Pugazhenthi, Subbiah — VA Eastern Colorado Health Care System
- Study coordinator: Pugazhenthi, Subbiah
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.