Investigating how Sirt2 affects T cell metabolism in cancer treatment
Role of Sirt2 in T Cell Metabolism
This study is looking at a protein called Sirt2 to see how it can help T cells, which are important for fighting cancer, work better during treatment by improving their energy and function in the tough environment of tumors.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Jacksonville NIH-funded |
| Lab location | 1 site (Jacksonville, United States) |
| Project ID | NIH-11036259 on NIH RePORTER |
What this research studies
This research explores the role of Sirt2, a protein that regulates T cell metabolism, in enhancing the effectiveness of cancer immunotherapy. It focuses on how T cells, which are crucial for fighting tumors, often struggle due to competition with cancer cells for resources in the tumor environment. By understanding how Sirt2 impacts T cell energy production and function, the study aims to develop strategies to improve T cell responses against tumors, potentially leading to better outcomes for patients undergoing cancer treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are cancer patients who are undergoing immunotherapy and may benefit from enhanced T cell function.
Not a fit: Patients with non-cancerous conditions or those not receiving immunotherapy may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved cancer immunotherapy by enhancing the effectiveness of T cells in attacking tumors.
How similar studies have performed: Previous research has shown promising results in enhancing T cell function through metabolic interventions, suggesting that this approach could be effective.
Where this research is happening
Jacksonville, United States
- Mayo Clinic Jacksonville — Jacksonville, United States (Active)
Researchers
- Principal investigator: Kim, Sungjune — Mayo Clinic Jacksonville
- Study coordinator: Kim, Sungjune
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.