Investigating how silent brain ischemia affects Alzheimer's dementia and exploring laser treatment options.
Official title: Silent brain ischemia accelerates Alzheimer's dementia: pathogenesis and laser treatment
Funded at Louisiana State Univ Hsc Shreveport · NIH-11032028 · Data updated 2026-11-12
This study is looking at how silent brain ischemia might lead to Alzheimer's and whether pulsed laser therapy can help protect the brain, especially for people who have had silent strokes or brain issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Louisiana State Univ Hsc Shreveport NIH-funded |
| Lab location | 1 site (Shreveport, United States) |
| Project start | February 15, 2024 |
| Project end | January 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $715,072 |
| NIH project number | 5R01AG082207-02 |
| Project ID | NIH-11032028 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include older adults who have experienced silent strokes or have been diagnosed with silent brain ischemia.
✕Less likely to help
Patients who do not have a history of silent brain ischemia or Alzheimer's disease may not benefit from this research.
What this research studies
This research focuses on understanding the impact of silent brain ischemia (SBI) on the development of Alzheimer's dementia. It aims to identify the mechanisms by which SBI contributes to cognitive decline and to evaluate the effectiveness of pulsed laser therapy as a potential treatment. The study will utilize innovative techniques to enhance the laser's ability to penetrate brain tissue, providing insights into its protective effects against Alzheimer's disease. Patients with a history of silent strokes or brain ischemia may find this research particularly relevant.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that prevent or slow the progression of Alzheimer's dementia in patients with silent brain ischemia.
How similar studies have gone: Previous research has shown promising results with laser therapy in treating brain injuries and neurodegeneration, suggesting potential for success in this novel application.
Where this research is happening
-
Louisiana State Univ Hsc Shreveport
Shreveport, United States Active
Researchers
- Principal investigator: Zhang, Quanguang — Louisiana State Univ Hsc Shreveport
- Study coordinator: Zhang, Quanguang
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.