Investigating how signals and mechanics affect the spread of pediatric bone cancer.
Cancer Biology Research Test-Bed Unit 1: Effects of cell-intrinsic and cell-extrinsic signaling and mechanics on metastasis patterns of pediatric sarcomas
This study is looking at how Ewing sarcoma, a type of cancer that mostly affects kids and young adults, spreads in the body, and it hopes to find new ways to treat it by understanding how cancer cells behave in their surroundings.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-10903855 on NIH RePORTER |
What this research studies
This research focuses on Ewing sarcoma, a type of bone and soft tissue cancer that primarily affects children and young adults. It aims to understand how both internal cell factors and external signals influence the behavior of cancer cells as they spread to other parts of the body. By examining the unique characteristics of these cells in their environment, the study seeks to uncover new insights that could lead to better treatment strategies. The research employs advanced techniques to analyze cell behavior at various levels, from whole organisms down to single cells.
Who could benefit from this research
Good fit: Ideal candidates for this research are children and young adults diagnosed with Ewing sarcoma, particularly those who have experienced metastasis.
Not a fit: Patients with other types of cancers or those whose Ewing sarcoma has not metastasized may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options and better survival rates for children and young adults with metastatic Ewing sarcoma.
How similar studies have performed: While there has been significant research on Ewing sarcoma, this approach to understanding metastasis through cell signaling and mechanics is relatively novel and has not been extensively tested.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Amatruda, James F — Ut Southwestern Medical Center
- Study coordinator: Amatruda, James F
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.