Investigating how signal peptides influence growth factor signaling in cells
Signal peptides and growth factor signaling
This study is looking at how certain signals help guide important proteins, like VEGF and its receptor, to the right places in our bodies, which is key for healing and growth, and it hopes to find new ways to treat diseases that affect blood vessel formation.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-11047738 on NIH RePORTER |
What this research studies
This research explores the role of signal peptides in directing proteins to specific locations within and outside cells, which is crucial for various biological processes. It focuses on the vascular endothelial growth factor (VEGF) and its receptor, VEGFR-2, which are vital for angiogenesis, a process important for development and healing. By studying the interactions between these proteins and their regulatory mechanisms, the research aims to uncover new insights that could lead to innovative treatments for diseases related to blood vessel formation and dysfunction.
Who could benefit from this research
Good fit: Ideal candidates for this research include adults with ischemia-related cardiovascular diseases, diabetic retinopathy, or malignancies.
Not a fit: Patients with conditions unrelated to angiogenesis or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for conditions like cardiovascular diseases and cancer by targeting the mechanisms of angiogenesis.
How similar studies have performed: Previous research has shown promising results in understanding the role of signal peptides in cellular signaling, indicating potential for success in this area.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Sadeghi, Mehran M — Yale University
- Study coordinator: Sadeghi, Mehran M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.