Investigating how sialylation affects communication between brain cells and stress responses
Official title: The role of sialylation in glia-neuron communications and stress responses
Funded at Texas A&m Agrilife Research · NIH-10928423 · Data updated 2026-11-12
This study is looking at how a special sugar process in brain cells helps them communicate with each other, using fruit flies to learn more about how this affects brain function and could relate to neurological diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Texas A&m Agrilife Research NIH-funded |
| Lab location | 1 site (College Station, UNITED STATES) |
| Project start | September 20, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $364,448 |
| NIH project number | 1R56NS129122-01A1 |
| Project ID | NIH-10928423 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with neurological conditions that may be linked to glycosylation defects.
✕Less likely to help
Patients with neurological disorders not associated with sialylation or glycosylation issues may not benefit from this research.
What this research studies
This research explores the role of sialylation, a specific type of glycosylation, in the communication between glial cells and neurons in the brain. Using the fruit fly Drosophila as a model organism, the study aims to uncover the molecular and genetic mechanisms that govern these processes. By employing both in vitro and in vivo methodologies, the research seeks to understand how sialylation impacts neural excitability and the development of neuromuscular junctions, which are critical for proper brain function. The findings could provide insights into the underlying causes of neurological diseases linked to sialylation defects.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for neurological diseases associated with sialylation abnormalities.
How similar studies have gone: Previous studies have shown promising results in understanding glycosylation's role in neural functions, indicating that this approach has potential for success.
Where this research is happening
-
Texas A&m Agrilife Research
College Station, United States Active
Researchers
- Principal investigator: Panin, Vladislav M — Texas A&m Agrilife Research
- Study coordinator: Panin, Vladislav M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.