Investigating how SGLT2 inhibitors affect inflammation and blood vessel function in obesity
Official title: The Effect of SGLT2 Inhibition on Adipose Tissue Inflammation and Endothelial Function
Funded at Vanderbilt University Medical Center · NIH-10869865 · Data updated 2026-11-12
This study is looking at how a type of medication called SGLT2 inhibitors can help reduce inflammation and improve blood vessel health in people who are obese and have pre-diabetes, and it will involve taking the medication for 12 weeks while we check how it affects your health.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $185,436 |
| NIH project number | 5K23HL159351-02 |
| Project ID | NIH-10869865 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are obese individuals who have pre-diabetes.
✕Less likely to help
Patients who are not obese or do not have pre-diabetes may not benefit from this research.
What this research studies
This research focuses on understanding how SGLT2 inhibitors, a type of medication, can reduce inflammation in fat tissue and improve blood vessel function in obese individuals with pre-diabetes. The study will involve treating participants with SGLT2 inhibitors for 12 weeks to observe changes in inflammation and cardiovascular health. By combining expertise in clinical study design and immunology, the research aims to fill gaps in knowledge about the cardiovascular benefits of these medications. Participants will be closely monitored to assess the effects of the treatment on their health.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that reduce inflammation and improve cardiovascular health in obese individuals.
How similar studies have gone: Previous research has shown that SGLT2 inhibitors have anti-inflammatory effects in animal models, suggesting potential success in human studies.
Where this research is happening
-
Vanderbilt University Medical Center
Nashville, United States Active
Researchers
- Principal investigator: Mashayekhi, Mona — Vanderbilt University Medical Center
- Study coordinator: Mashayekhi, Mona
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.