Investigating how Sez6 proteins protect synapses from being removed by the immune system
Sez6 proteins as protection factors in complement-mediated synaptic pruning
This study is looking at how certain proteins in the brain help control the removal of connections between brain cells, which is important for healthy brain development, and it aims to find ways to use this knowledge to help people with conditions like autism and schizophrenia improve their thinking and movement skills.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-11059206 on NIH RePORTER |
What this research studies
This research explores the role of Sez6 proteins in regulating the immune system's pruning of synapses, which is crucial for brain development. It focuses on how these proteins may prevent excessive synaptic removal that can contribute to neurodevelopmental disorders like autism and schizophrenia. By studying the mechanisms of complement-mediated synaptic pruning, the research aims to identify potential therapeutic targets for improving cognitive and motor functions in affected individuals. Patients may benefit from insights into how these proteins can be leveraged to protect brain function.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with autism spectrum disorder, schizophrenia, or related neurodevelopmental conditions.
Not a fit: Patients with neurodevelopmental disorders not related to synaptic pruning or those without a diagnosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance cognitive and motor functions in individuals with autism and related disorders.
How similar studies have performed: Previous research has shown promising results in understanding the role of immune factors in neurodevelopmental disorders, suggesting that this approach may yield significant insights.
Where this research is happening
Rochester, United States
- University of Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Hammond, Jennetta W — University of Rochester
- Study coordinator: Hammond, Jennetta W
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.